Which treatment is suggested for mild to moderate cocaine intoxication agitation?

In the context of treating mild to moderate cocaine intoxication with symptoms of agitation, benzodiazepines are considered an appropriate intervention. They are effective because they provide rapid sedation and help to decrease agitation, anxiety, and psychomotor stimulation without exacerbating the stimulant effects of cocaine. This calming effect can alleviate acute symptoms in a safe manner.

Benzodiazepines act by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the brain. This action helps to counteract the heightened arousal and excitability associated with cocaine use. They can also assist in the management of any associated anxiety or agitation, leading to a more controlled and stable environment for the patient.

Other treatment modalities, such as antipsychotics like haloperidol, might be less preferable initially because they can increase the risk of extrapyramidal symptoms or may not effectively address the specific agitation associated with stimulant intoxication. SSRIs, while useful in the context of depression and anxiety, do not provide the immediate relief needed for acute agitation in this scenario. Stimulants would further compound the problem by increasing agitation and aren't indicated in cases of cocaine intoxication.

Therefore, benzodiazepines are the