Which of the following is a characteristic of Major Depressive Disorder's diagnostic criteria?

Major Depressive Disorder (MDD) is characterized by specific diagnostic criteria outlined in the DSM-5, one of which is the absence of a prior history of hypomanic or manic episodes. This criterion is crucial because it differentiates MDD from Bipolar Disorder, where manic or hypomanic episodes are present. The requirement ensures that a diagnosis of MDD is appropriate, as the presence of manic episodes would suggest a different disorder.

Additionally, for a diagnosis of MDD, the individual must exhibit a certain number of symptoms (such as persistent sadness or loss of interest) for a minimum duration. This ensures the diagnosis reflects a significant impact on functioning or well-being, distinct from other mood disorders. Therefore, the absence of a history of hypomanic episodes is a key characteristic in confirming the diagnosis of Major Depressive Disorder rather than a bipolar condition.