Which neurochemical is primarily associated with Obsessive-Compulsive Disorder?

The neurochemical primarily associated with Obsessive-Compulsive Disorder (OCD) is serotonin. Research indicates that dysregulation of the serotonin system plays a significant role in the pathophysiology of OCD. Evidence from studies suggests that individuals with OCD often exhibit altered serotonin metabolism.

Several first-line treatments for OCD, including selective serotonin reuptake inhibitors (SSRIs), work to increase serotonin levels in the synaptic cleft, which has been shown to alleviate symptoms of the disorder. Additionally, cognitive-behavioral therapy (CBT), particularly exposure and response prevention, often leads to changes in serotonin functioning as treatment progresses.

While dopamine, norepinephrine, and acetylcholine are important neurotransmitters that are involved in various psychiatric conditions and can influence mood and anxiety, they do not have the same direct and robust association with OCD as serotonin does. This makes serotonin the key neurochemical linked to the development and treatment of obsessive-compulsive symptoms.