Which gender is more commonly affected by Rett's Disorder?

Rett's Disorder, also known as Rett Syndrome, predominantly affects girls. The condition is caused by mutations in the MECP2 gene, which is located on the X chromosome. Because girls have two X chromosomes, they have a backup copy of the gene; however, when the MECP2 gene is mutated, it can lead to severe neurodevelopmental issues primarily in females. Boys are rarely affected by Rett's Disorder and tend to have more severe outcomes if they do inherit the mutation, often resulting in early lethality. This gender disparity is a significant aspect of the disorder, solidifying that girls are the primary demographic affected.