What is a distinguishing effect of MDMA compared to other amphetamines?

MDMA, commonly known as ecstasy, is distinguished from other amphetamines primarily by its ability to significantly stimulate the release of serotonin. While amphetamines in general can increase dopamine levels and may also affect norepinephrine, MDMA's unique effect comes from its potent and selective action on serotonin transporters, leading to a release of large amounts of serotonin in the brain. This serotonergic effect is responsible for many of the psychedelic and empathogenic experiences associated with MDMA use, including enhanced emotional closeness, mood elevation, and altered sensory perception.

In contrast, while increased heart rate and stimulation of dopamine release can occur with various stimulant substances, they do not reflect the unique serotonergic properties that set MDMA apart. Additionally, decreased appetite is more typical of traditional amphetamines, whereas MDMA's effects are more focused on mood and sensory experience rather than appetite suppression. Thus, the stimulation of serotonin release is the primary distinguishing factor of MDMA compared to other amphetamines.